First US woman gives birth with transplanted womb from deceased donor

For the first time in the US the Cleveland Clinic delivered a baby from a uterus that was transplanted from a deceased donor

Mother and baby are said to be doing well following the birth in June.

Dr Uma Perni, the clinic’s maternal fetal medicine specialist, said they couldn’t have wished for more success.

“We couldn’t have asked for a better outcome. Everything went wonderfully with the delivery; the mother and baby girl are doing great. “It’s important to remember this is still research. The field of uterus transplantation is rapidly evolving, and it’s exciting to see what the options may be for women in the future.”

The transplant and birth are part of an on-going clinical trial for Uterine Transplantation for the Treatment of Uterine Factor Infertility at Cleveland Clinic, offering hope to women worldwide who are unable to have a baby due to uterine factor infertility.

An estimated one in 500 women of childbearing age worldwide are affected by the irreversible condition

In June, the research team – comprised of specialists in transplant surgery, obstetrics and gynecology, fertility, neonatology, bioethics, psychiatry, nursing, anesthesiology, infectious disease, interventional radiology, patient advocacy and social work – welcomed a baby girl via cesarean section.

The uterus, from a deceased donor, was transplanted in late 2017. In late 2018, the mother, who is in her mid-30s, became pregnant through in vitro fertilization.

The first woman in the world to have a child via a donor womb was 34-year-old Claudio Santos, from Sao Paulo, Brazil

“It was amazing how perfectly normal this delivery was, considering how extraordinary the occasion,” says Cleveland Clinic transplant surgeon Dr Andreas Tzakis. “Through this research, we aim to make these extraordinary events, ordinary for the women who choose this option. We are grateful to the donor and her family, their generosity allowed our patient’s dream to come true and a new baby to be born.”

Since Cleveland Clinic began the clinical trial, the team has completed five uterus transplants

Three transplants were successful and two resulted in hysterectomies. Currently, two women are awaiting embryo transfers, while several more candidates are listed for transplant.

The aim is to enroll ten women between the ages of 21 and 39 years old

Unlike similar research efforts in the US, Cleveland Clinic’s protocol calls for the transplanted uterus to come from a deceased donor in order to eliminate risk to a healthy, living donor.

For more information about Cleveland Clinic’s uterine transplant program, visit here

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