It’s tough and disappointing if the doctor at your fertility clinic tells you for the second or third time that a pregnancy hasn’t happened
Both you and your partner are deeply affected and are in despair. That longing-for a baby increases furthermore.
Odd as it seems, the best thing for both of you to do is to stay hopeful.
Keep your optimism alive if you decide to have IVF again, but of course there are other steps that you must take.
The first is, that no matter how painful, talk to your doctor and find out why IVF may have failed more than once.
Here are some of the causes that your doctor may talk to you about.
The first possible cause could be that the embryos were either not “morphologically good” (well formed) or they were implanted too early. The norm now is to wait for what is called the ‘blastocyst stage’ – which is the 5th day after fertilisation. But many centres do the implantation on day 2 or 3, which may be good for the centre, but not so good for you.
If the repeated IVF failures occurred even when “morphologically good” (well formed) embryos were transferred, the question is whether these ‘good’ embryos are chromosomally normal [euploid – having the full 46 chromosomes]. A suitable genetic test [Pre-Implantation Genetic Testing] may be able to discover if this is the case.
Treatment then involves developing embryos and analysing each one so that only those free of chromosomal abnormalities are implanted.
If done correctly, this has a high chance of success.
The other major cause of IVF failing is an implantation dysfunction i.e. the uterus may not be ready to accept the embryos. It is possible to test the endometrial receptivity by suitable tests [ERA].
Failed implantation may be due to the endometrium, to the embryo or to a lack of communication between the two
Some of the most common causes of implantation dysfunction are:
- a thin uterine lining
- a uterus with surface lesions in the cavity (polyps, fibroids, scar tissue)
- immunologic implantation dysfunction (IID)
The third could be due to healthy embryos failing to implant in the uterus – sometimes because the mother’s body produces antibodies which prevents the embryos implanting.
If the doctor is open and candid with you and that there’s nothing to worry about.
Go ahead and try again, but only after adequate tests and examinations have been done.
But if the centre or doctor is reluctant to discuss possible causes of your failures it means one of two things: yours is one of those cases of “unexplained IVF failure” or its time to look for a new clinic for your next cycle!
Sending all the best from The Team at Nova IVI Fertility. We are here for you if you would like to discuss this or have any other fertility queries.
To get in touch with Nova IVI Fertility click here.